2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W050087
    Octaethylene glycol 5117-19-1 99.97%
    Octaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Octaethylene glycol
  • HY-140070
    endo-BCN-PEG8-NHS ester 1608140-48-2
    endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG8-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG8-NHS ester
  • HY-130525
    Iodo-PEG3-N3 936917-36-1
    Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodo-PEG3-N3
  • HY-141362
    Bromo-PEG2-C2-acid 1807503-92-9 99.73%
    Bromo-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-C2-acid
  • HY-W010948
    Diethylene glycol bis(p-toluenesulfonate) 7460-82-4 99.83%
    Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diethylene glycol bis(p-toluenesulfonate)
  • HY-140735
    DSPE-PEG-Amine, MW 5000
    DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Amine, MW 5000
  • HY-W003696
    tert-Butyl 5-bromoisoindoline-2-carboxylate 201940-08-1 99.44%
    tert-Butyl 5-bromoisoindoline-2-carboxylate (Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate) is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
    tert-Butyl 5-bromoisoindoline-2-carboxylate
  • HY-W190962
    t-Boc-N-amido-PEG5-acetic acid 890152-41-7 99.91%
    BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-N-amido-PEG5-acetic acid
  • HY-140928
    Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne 2241685-22-1
    Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne
  • HY-114512
    m-PEG1-NHS ester 1027371-75-0
    m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG1-NHS ester
  • HY-135048
    Mal-PEG4-OH 1421933-37-0
    Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG4-OH
  • HY-141231
    Heptaethylene glycol 5617-32-3
    Heptaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Heptaethylene glycol
  • HY-140480
    Acid-PEG2-C2-Boc 2086688-99-3 ≥98.0%
    Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG2-C2-Boc
  • HY-133479
    Tetrazine-Ph-NHCO-C3-NHS ester 1244040-64-9 98.40%
    Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHCO-C3-NHS ester
  • HY-133402
    BCN-​exo-​PEG3-​NH2 1841134-72-2 99.94%
    BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    BCN-​exo-​PEG3-​NH2
  • HY-140663
    Azide-PEG-amine (MW 5000)
    Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-amine (MW 5000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-amine (MW 5000)
  • HY-W042713
    Pentaethylene glycol monomethyl ether 23778-52-1 99.87%
    Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol monomethyl ether
  • HY-130169
    Azido-PEG9-amine 1207714-69-9 98.52%
    Azido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-amine
  • HY-133174
    Biotin-PEG5-azide 1163732-89-5
    Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG5-azide
  • HY-140459
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9 98.59%
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.