2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-135915
    Biotin-C5-NHS Ester 72040-63-2 ≥98.0%
    Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-C5-NHS Ester
  • HY-135933
    Boc-NH-PEG8-CH2CH2NH2 1052207-59-6 99.93%
    Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG8-CH2CH2NH2
  • HY-133393
    Azido-PEG6-azide 1243536-56-2
    Azido-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-azide
  • HY-40144
    Azetidin-3-ol hydrochloride 18621-18-6 99.74%
    Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.
    Azetidin-3-ol hydrochloride
  • HY-140135
    PC-Biotin-PEG4-NHS carbonate 2055198-03-1
    PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PC-Biotin-PEG4-NHS carbonate
  • HY-W007529
    Boc-6-aminohexanoic acid 6404-29-1 ≥98.0%
    Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-6-aminohexanoic acid
  • HY-W007322
    Boc-NH-PEG1-OH 26690-80-2 99.65%
    Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG1-OH
  • HY-130194
    Azido-PEG5-CH2CO2H 217180-81-9 98.88%
    Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-CH2CO2H
  • HY-130342
    HO-PEG11-OH 6809-70-7 99.41%
    HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG11-OH
  • HY-130334
    Mal-PEG8-acid 1818294-46-0 98.10%
    Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG8-acid
  • HY-23105
    Amino-PEG6-amine 76927-70-3
    Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG6-amine
  • HY-44141
    tert-Butyl 3-(2-iodoethoxy)propanoate 2296723-16-3
    tert-Butyl 3-(2-iodoethoxy)propanoate is a PROTAC linker, which refers to the PEG composition. tert-Butyl 3-(2-iodoethoxy)propanoate can be used in the synthesis of PROTAC FAK degrader 1 (HY-119932).
    tert-Butyl 3-(2-iodoethoxy)propanoate
  • HY-136158A
    6-Maleimidocaproic acid sulfo-NHS sodium 215312-86-0 98.91%
    6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocaproic acid sulfo-NHS sodium
  • HY-130871A
    HS-PEG3-CH2CH2NH2 hydrochloride
    HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HS-PEG3-CH2CH2NH2 hydrochloride
  • HY-138466
    Azido-PEG3-C6-Cl 1625717-44-3
    Azido-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C6-Cl
  • HY-140679
    mPEG-amine (MW 20000) 80506-64-5 ≥98.0%
    m-PEG-NH2 (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-amine (MW 20000)
  • HY-130572
    Azido-PEG5-acid 1425973-16-5 ≥98.0%
    Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-acid
  • HY-141362
    Bromo-PEG2-C2-acid 1807503-92-9 99.73%
    Bromo-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-C2-acid
  • HY-140735
    DSPE-PEG-Amine, MW 5000
    DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Amine, MW 5000
  • HY-140902A
    Biotin-PEG3-C3-NH2 183896-00-6
    Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs.
    Biotin-PEG3-C3-NH2
PROTAC Linkers Isoform Comparison

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